Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (6): 1407-1411.DOI: 10.6023/cjoc201601010 Previous Articles     Next Articles

Notes

无溶剂熔融条件下5-[(3-吲哚基)-芳甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮类化合物的绿色合成

吕成伟, 刘妍杭, 周晓霞   

  1. 辽宁师范大学化学化工学院大连 116029
  • 收稿日期:2016-01-10 修回日期:2016-02-01 出版日期:2016-06-25 发布日期:2016-02-24
  • 通讯作者: 吕成伟 E-mail:chengweilv@126.com
  • 基金资助:

    国家自然科学基金(No.21403100)和辽宁省博士启动基金(No.20141100)资助项目.

Efficient and Green Synthesis of 5-[(Indole-3-yl)-arylmethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives in the Melt

Lü Chengwei, Liu Yanhang, Zhou Xiaoxia   

  1. Shcool of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029
  • Received:2016-01-10 Revised:2016-02-01 Online:2016-06-25 Published:2016-02-24
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21403100), and the Doctoral Scientific Research Foundation of Liaoning Province (No. 20141100).

An efficient melting method for the synthesis of β-indole derivatives via Yonemitsu reaction was developed successfully using aldehyde, indole and Meldrum's acid as the starting materials and 50 μL water as green promoter without other solvent. A series of 5-[(indole-3-yl)-arylmethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives were synthesized in 55%~94% yields. The remarkable advantages of this reaction were mild reaction condition, easy operation, tolerant the substrates with diverse functional groups and environment-friendly.

Key words: melting method, multicomponent reaction, water, β-indole derivatives, green chemistry