Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (6): 1407-1411.DOI: 10.6023/cjoc201601010 Previous Articles     Next Articles



吕成伟, 刘妍杭, 周晓霞   

  1. 辽宁师范大学化学化工学院大连 116029
  • 收稿日期:2016-01-10 修回日期:2016-02-01 发布日期:2016-02-24
  • 通讯作者: 吕成伟
  • 基金资助:


Efficient and Green Synthesis of 5-[(Indole-3-yl)-arylmethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives in the Melt

Lü Chengwei, Liu Yanhang, Zhou Xiaoxia   

  1. Shcool of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029
  • Received:2016-01-10 Revised:2016-02-01 Published:2016-02-24
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21403100), and the Doctoral Scientific Research Foundation of Liaoning Province (No. 20141100).

An efficient melting method for the synthesis of β-indole derivatives via Yonemitsu reaction was developed successfully using aldehyde, indole and Meldrum's acid as the starting materials and 50 μL water as green promoter without other solvent. A series of 5-[(indole-3-yl)-arylmethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives were synthesized in 55%~94% yields. The remarkable advantages of this reaction were mild reaction condition, easy operation, tolerant the substrates with diverse functional groups and environment-friendly.

Key words: melting method, multicomponent reaction, water, β-indole derivatives, green chemistry