Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (7): 1501-1512.DOI: 10.6023/cjoc201601027 Previous Articles     Next Articles



刘文香a,b, 吴宇强a,b, 李灵芝b,c, 李霞b,c   

  1. a. 天津医科大学药学院 天津 300070;
    b. 武警后勤学院药物化学教研室 天津 300309;
    c. 天津市职业与环境危害防制重点实验室 天津 300309
  • 收稿日期:2016-01-20 修回日期:2016-03-01 发布日期:2016-03-28
  • 通讯作者: 李霞
  • 基金资助:


Progress on the Asymmetric Diels-Alder Reaction of α,β-Unsaturated Carbonyl Compounds

Liu Wenxianga,b, Wu Yuqianga,b, Li Lingzhib,c, Li Xiab,c   

  1. a. Pharmaceutial College, Tianjin Medical University, Tianjin 300070;
    b. Department of Pharmaceutical Chemistry, Logistic University of PAP, Tianjin 300309;
    c. Tianjin Key Laboratory for Prevention and Control of Occupational and Environmental Hazards, Tianjin 300309
  • Received:2016-01-20 Revised:2016-03-01 Published:2016-03-28
  • Supported by:

    Project supported by the Doctoral Operation Foundation of Medical College of PAP (No. WHB201506) and the Innovative Research Team Program for Scienec and Technology in Logistics University of PAP (No. WHTD201303).

Diels-Alder reaction is a [4+2] concerted cycloaddition reaction, which has attracted considerable attention since its discovery. Asymmetric Diels-Alder reaction is an effective method for synthesis of chiral intermediates, so it was widely applied in the total synthesis of drugs and natural products. α,β-Unsaturated carbonyl compounds are a kind of highly reactive versatile intermediates in organic synthesis, according to its structural characteristics and catalytic types, recent advances in asymmetric normal electron-demand Diels-Alder reaction of α,β-unsaturated carbonyl compounds are reviewed in this paper.

Key words: asymmetric Diels-Alder reaction, natural product, organic synthesis, α,β-unsaturated carbonyl compounds