Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (1): 237-241.DOI: 10.6023/cjoc201605021 Previous Articles     Next Articles



林玉萍a, 虎春艳a, 郑喜b, 王秀丽a, 万春平b, 毛泽伟a   

  1. a 云南中医学院中药学院 昆明 650500;
    b 云南中医学院第一附属医院中心实验室 昆明 650021
  • 收稿日期:2016-05-12 修回日期:2016-06-20 发布日期:2016-07-15
  • 通讯作者: 毛泽伟
  • 基金资助:

    国家自然科学基金(No. 81460624)和云南省教育厅基金(No. 2014Z119)资助项目.

Synthesis and Anti-tumor Activities of Novel 4'-(N-Substitued-1-piperazinyl) chalcone Derivatives

Lin Yupinga, Hu Chunyana, Zheng Xib, Wang Xiulia, Wan Chunpingb, Mao Zeweia   

  1. a School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500;
    b Central Laboratory, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming 650021
  • Received:2016-05-12 Revised:2016-06-20 Published:2016-07-15
  • Supported by:

    Project supported by theNational Natural Science Foundation of China(No. 81460624) and the Foundation of Yunnan Province Department of Education(No. 2014Z119).

With the aim of developing new potent anticancer agents,a series of novel 4'-(N-substitued-1-piperazinyl) chalcone derivatives 3a~3j have been designed and synthesized based on the structure of the chalcone by molecular hybridization.The structures were characterized by 1H NMR,13C NMR and HRMS.These derivatives were evaluated for their in vitro anti-tumor activity against a panel of human tumor cell lines(Hela,A549 and SGC7901) by the thiazolyl blue tetrazolium bromide(MTT) assay.The result indicated that compounds 3f,3i and 3j were found to be the potent compounds against human tumor cell lines,which are to be lead compounds for further structural modifications and activity research.

Key words: chalcone, piperazine, synthesis, anti-tumor activity