Synthesis and Biological Activity of 1,2,4-Triazole Thioether Derivatives Containing Pyrazole Moiety

doi:10.6023/cjoc201607031

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (1): 232-236.DOI: 10.6023/cjoc201607031 Previous Articles Next Articles

NOTE

新型含吡唑的三唑硫醚类化合物的合成与生物活性研究

翟志文, 汪乔, 沈钟华, 谭成侠, 翁建全, 刘幸海

浙江工业大学化学工程学院杭州 310014

收稿日期:2016-07-20 修回日期:2016-08-25 发布日期:2016-09-01
通讯作者: 刘幸海 E-mail:xhliu@zjut.edu.cn
基金资助:
浙江省自然科学基金（No. LY16C14007）和浙江省科技厅科研院所专项（No. 2015F50030）资助项目.

Synthesis and Biological Activity of 1,2,4-Triazole Thioether Derivatives Containing Pyrazole Moiety

Zhai Zhiwen, Wang Qiao, Shen Zhonghua, Tan Chengxia, Weng Jianquan, Liu Xinghai

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014

Received:2016-07-20 Revised:2016-08-25 Published:2016-09-01
Supported by:
Project supported by the Zhejiang Provincial Science Foundation of China(No. LY16C14007) and the Research Institute Special Program of Department of Science and Technology of Zhejiang Province(No. 2015F50030).

A series of novel 1,2,4-triazole derivatives were synthesized from ethyl trifluoroacetoacetate,triethyl orthoformate,methylhydrazine,phenyl isothiocyanate by multi-step reactions.Their structures were characterized by ¹H NMR,¹³C NMR,HRMS and X-ray diffraction.The target compounds were evaluated for their fungicidal activity and herbicidal activitiy.The results indicated that some of the title compounds displayed certain fungicidal activities against Colletotrichum orbiculare and herbicidal activity against dicotyledons.

Key words: pyrazole, 1,2,4-triazole, synthesis, fungicidal activity, herbicidal activity

Cite this article

Zhai Zhiwen, Wang Qiao, Shen Zhonghua, Tan Chengxia, Weng Jianquan, Liu Xinghai. Synthesis and Biological Activity of 1,2,4-Triazole Thioether Derivatives Containing Pyrazole Moiety[J]. Chin. J. Org. Chem., 2017, 37(1): 232-236.

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新型含吡唑的三唑硫醚类化合物的合成与生物活性研究

Synthesis and Biological Activity of 1,2,4-Triazole Thioether Derivatives Containing Pyrazole Moiety

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