Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (7): 1629-1652.DOI: 10.6023/cjoc201702048 Previous Articles     Next Articles



李其林a,b, 张洪彬b   

  1. a. 云南省地震局 昆明 650224;
    b. 云南大学教育部自然资源药物化学重点实验室 昆明 650091
  • 收稿日期:2017-01-28 修回日期:2017-03-22 发布日期:2017-04-13
  • 通讯作者: 张洪彬
  • 基金资助:


Research Progress on the Synthesis of Morphine Alkaloids

Li Qilina,b, Zhang Hongbinb   

  1. a. Earthquake Administration of Yunnan Province, Kunming 650224;
    b. Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education, Yunnan University, Kunming 650091
  • Received:2017-01-28 Revised:2017-03-22 Published:2017-04-13
  • Contact: 10.6023/cjoc201702048
  • Supported by:

    Project supported by the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT13095),and the National Natural Science Foundation of China (Nos.20925205,21332007).

The morphine alkaloids constitute a class of structurally related natural products isolated from opium poppy, Papaver somniferum. The synthesis of morphine and its derivatives has attracted the attention of many generations of synthetic chemists due to their highly challenging molecular architecture and biological activities. Progresses toward the synthesis of the morphine alkaloids are reviewed in terms of chronological order.

Key words: morphine, morphine alkaloids, synthesis