Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (4): 969-974.DOI: 10.6023/cjoc201710010 Previous Articles     Next Articles



刘天宝, 彭艳芬, 王雅洁, 雍家远, 汪新   

  1. 池州学院化学与材料工程学院 池州 247000
  • 收稿日期:2017-10-09 修回日期:2017-11-21 发布日期:2017-12-05
  • 通讯作者: 刘天宝
  • 基金资助:


Synthesis of Thioamidoguanidine Derivatives under Solvent-Free Grinding Conditions

Liu Tianbao, Peng Yanfen, Wang Yajie, Yong Jiayuan, Wang Xin   

  1. Department of Chemical and Material Engineering, Chizhou University, Chizhou 247000
  • Received:2017-10-09 Revised:2017-11-21 Published:2017-12-05
  • Contact: 10.6023/cjoc201710010
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21271035), the Major Basic Research Project of the Natural Science Foundation of the Anhui Province Education Department (No. KJ2016A512) and the Key Program in the Youth Elite Support Plan in Universities of Anhui Province (No. gxyqZD2016372).

The in situ generated aryl-alkyl unsymmetrical thioureas were prepared by the reaction of aryl isothiocyanate with cyclic aliphatic secondary amine. Then, the thioamidoguanidino derivatives instead of the expected Hugerschoff product 2-aminobenzothiazole were obtained from unsymmetrical thioureas using iodosobenzene diacetate and Et3N under solvent-free grinding conditions. The advantages of this procedure are simple operation, mild reaction conditions, and solvent-free. The products were identified by IR, HRMS, 1H NMR and 13C NMR. The reported method is an efficient approach for the synthesis of thioamidoguanidine derivatives.

Key words: solvent-free, thioamidoguanidine, iodosobenzene diacetate, aryl isothiocyanate