Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (4): 975-980.DOI: 10.6023/cjoc201710030 Previous Articles     Next Articles

Notes

3-膦酰基吡喃骈[3,2-c]吡唑-7(1H)-酮的合成

陈波a, 刘为顺a, 张建芳a, 刘佳怡a, 邓桂胜a,b   

  1. a 湖南师范大学 化学生物学与中药研究重点实验室(教育部) 长沙 410081;
    b 湖南师范大学 有机功能分子组装与应用重点实验室 长沙 410081
  • 收稿日期:2017-10-24 修回日期:2017-11-26 发布日期:2017-12-05
  • 通讯作者: 邓桂胜 E-mail:gsdeng@hunnu.edu.cn
  • 基金资助:

    国家自然科学基金(No.21372071)、湖南省自然科学基金(No.2016JJ2080)资助项目.

Synthesis of 3-Phosphonyl Pyrano[3,2-c]pyrazol-7(1H)-one

Chen Boa, Liu Weishuna, Zhang Jianfanga, Liu Jiayia, Deng Guishenga,b   

  1. Ministry of Education of China), Hunan Normal University, Changsha 410081;
    b Key Laboratory of the Assembly and Application of Organic Functional Molecules, Hunan Normal University, Changsha 410081
  • Received:2017-10-24 Revised:2017-11-26 Published:2017-12-05
  • Contact: 10.6023/cjoc201710030 E-mail:gsdeng@hunnu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21372071) and the Hunan Provincial Natural Science Foundation of China (No. 2016JJ2080).

Base-mediated cyclization of 1-diazo-2,4-dioxo-5-ynylphosphonate provided novel 3-phosphonyl pyrano[3,2-c] pyrazol-7(1H)-one derivatives in 48%~99% yields. Mild conditions, simple manipulation and functional group diversity are the salient features of this methodology.

Key words: synthesis, base, cyclization, pyrano[3,2-c]pyrazol-7(1H)-one, phosphonate