Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (4): 846-854.DOI: 10.6023/cjoc201711014 Previous Articles     Next Articles



高歌a, 王萍b, 刘鹏a, 张卫红a, 默丽萍a, 张占辉a   

  1. a 河北师范大学化学与材料科学学院 化学国家级实验教学示范中心 石家庄 050024;
    b 河北化工医药职业技术学院 化学与环境工程系 石家庄 050026
  • 收稿日期:2017-11-08 修回日期:2017-12-05 发布日期:2017-12-15
  • 通讯作者: 张占辉,
  • 基金资助:


Deep Eutectic Solvent Catalyzed One-Pot Synthesis of 4,7-Dihydro-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles

Gao Gea, Wang Pingb, Liu Penga, Zhang Weihonga, Mo Lipinga, Zhang Zhanhuia   

  1. a National Demonstration Center for Experimental Chemistry Education, College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024;
    b Department of Chemical and Environmental Engineering, Hebei Chemical and Pharmaceutical Vocational Technology College, Shijiazhuang 050026
  • Received:2017-11-08 Revised:2017-12-05 Published:2017-12-15
  • Contact: 10.6023/cjoc201711014,
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21272053) and the Natural Science Foundation of Hebei Province (No. B2015205182).

Deep eutectic solvent based on L-proline and oxalic acid has been demonstrated for the first time as an efficient catalyst for synthesis of 4,7-dihydro-1H-pyrazolo[3,4-b] pyridine-5-carbonitrile derivatives via one-pot three-component reaction of aldehyde, 3-oxopropanenitrile and 1H-pyrazol-5-amine. The key features of this approach include the broad substrate scope, operational simplicity, recyclable catalyst and possibility to scale up giving multigram quantities.

Key words: deep eutectic solvent, multicomponent reaction, 4,7-dihydro-1H-pyrazolo[3,4-b] pyridine-5-carbonitrile, green chemistry