Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (11): 2858-2865.DOI: 10.6023/cjoc201805061 Previous Articles     Next Articles

Special Issue: 有机小分子-金属协同催化



孔黎春, 周雨露, 罗芳, 朱钢国   

  1. 浙江师范大学化学系 先进催化材料教育部重点实验室 金华 321004
  • 收稿日期:2018-05-31 修回日期:2018-06-27 发布日期:2018-07-24
  • 通讯作者: 朱钢国
  • 基金资助:


Recent Advances on Oxidative Radical Addition to Aldehydes

Kong Lichun, Zhou Yulu, Luo Fang, Zhu Gangguo   

  1. Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, Jinhua 321004
  • Received:2018-05-31 Revised:2018-06-27 Published:2018-07-24
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21672191).

Ketones are ubiquitous chemical entries in natural products, biologically active molecules, and functional materials. As such, developing operationally simple and general methods for the synthesis of these scaffolds is highly desiable. Recently, oxidative radical addition to aldehydes has emerged as a highly efficient strategy for the direct access of ketones. The strategy features a formal 1,2-hydrogen atom transfer of resulting alkoxy radicals, followed by single electron transfer oxidation and deprotonation to give various cyclic or acyclic ketones in promising yields with a broad substrate scope. Recent advances in this area, including both intramolecular and intermolecular versions, are discussed herein.

Key words: aldehyde, radical addition, ketone, 1,2-hydrogen atom transfer, single electron transfer