Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (9): 2185-2198.DOI: 10.6023/cjoc201806019 Previous Articles     Next Articles

Special Issue: 合成科学

Reviews

复杂天然产物全合成:化学合成与生物合成结合的策略

李晓军a, 张万斌c, 高栓虎a,b   

  1. a 华东师范大学化学与分子工程学院 上海市绿色化学与化工过程绿色化重点实验室 上海 200062;
    b 华东师范大学 上海分子治疗与新药创制工程技术研究中心 上海 200062;
    c 上海交通大学化学化工学院 上海 200240
  • 收稿日期:2018-06-14 修回日期:2018-07-09 出版日期:2018-09-25 发布日期:2018-07-16
  • 通讯作者: 张万斌, 高栓虎 E-mail:wanbin@sjtu.edu.cn;shgao@chem.ecnu.edu.cn
  • 基金资助:

    国家自然科学基金(No.21772044)、上海市优秀学术/技术带头人计划(No.18XD1401500)和中央高校基本科研业务费资助项目.

Total Synthesis of Complex Natural Products: Combination of Chemical Synthesis and Biosynthesis Strategies

Li Xiaojuna, Zhang Wanbinc, Gao Shuanhua,b   

  1. a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, Shanghai 200062;
    b Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062;
    c School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai 200240
  • Received:2018-06-14 Revised:2018-07-09 Online:2018-09-25 Published:2018-07-16
  • Contact: 10.6023/cjoc201806019 E-mail:wanbin@sjtu.edu.cn;shgao@chem.ecnu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21772044), the National Young Top-Notch Talent Support Program of Shanghai Academic/Technology Research Leader (No. 18XD1401500) and the Fundamental Research Funds for the Central Universities.

Total synthesis of natural products is one of the most important field in organic chemistry. Natural products and derivatives, containing complex structures and potential biological activities, are also indispensable sources of drug discovery. The total synthesis of natural products through the combination of chemical synthesis and biosynthesis strategies is reviewed. The main content includes the chemical and biosynthetic studies of artemisinin, spinosyn A, myceliothernophin E and equisetin.

Key words: total synthesis of natural products, chemical synthesis, biosynthesis