Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (12): 3165-3175.DOI: 10.6023/cjoc201806043 Previous Articles     Next Articles

Special Issue: 荧光探针-生物传感合辑 有机超分子化学合辑



吕卉a,b, 徐学涛a,b, 黄丹颖a,b, 吴盼盼a,b, 盛钊君a,b, 刘文锋a,b, 李冬利a,b, Njud S. Alharbic, 张焜a,b, 王少华a,b,d   

  1. a 五邑大学化学与环境工程学院 江门 529020;
    b 江门市大健康国际创新研究院 江门 529020;
    c Faculty of Science, King Abdulaziz University, Jeddah 999088;
    d 兰州大学药学院 兰州 730000
  • 收稿日期:2018-06-28 修回日期:2018-07-26 发布日期:2018-08-22
  • 通讯作者: 徐学涛, 王少华;
  • 基金资助:


Recent Progress on Endoplasmic Reticulum-Targetable Fluorescence Probe

Lü Huia,b, Xu Xuetaoa,b, Huang Danyinga,b, Wu Panpana,b, Sheng Zhaojuna,b, Liu Wenfenga,b, Li Donglia,b, Alharbi Njud S.c, Zhang Kuna,b, Wang Shaohuaa,b,d   

  1. a School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020;
    b International Healthcare Innovation Institute, Jiangmen 529000;
    c Faculty of Science, King Abdulaziz University, Jeddah 999088;
    d School of Pharmacy, Lanzhou University, Lanzhou 730000
  • Received:2018-06-28 Revised:2018-07-26 Published:2018-08-22
  • Contact: 10.6023/cjoc201806043;
  • Supported by:

    Project supported by the Department of Education of Guangdong Province (Nos. 2017KTSCX185, 2017KSYS010, 2016KCXTD005), the Youth Team Fund of Wuyi University, and the National Natural Science Foundation of China (Nos. 21472077, 21772071).

The endoplasmic reticulum, a subcellular organelle, plays an important role in the life activities of mammalian cells. Therefore, visualizing the endoplasmic reticulum, and further examining its active substances, microenvironments and physiological processes have important guiding value for the diagnosis and treatment of related diseases. In recent years, the design and synthesis of endoplasmic reticulum-targetable fluorescent probes have received more and more attentions. Currently, reported endoplasmic reticulum-targetable fluorescent probes mainly include simple endoplasmic reticulum imaging, metal ions, small molecule material, big molecule material, microenvironments, etc. This article summarizes and describes the design and synthesis of the reported endoplasmic reticulum-targetable fluorescent probes, analyzes the application of endoplasmic reticulum fluorescent probes in the study of cellular physiological processes, and prospects the development trend of endoplasmic reticulum-targetable fluorescent probes.

Key words: endoplasmic reticulum, fluorescence, imaging, probe, active small molecule