Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (4): 961-973.DOI: 10.6023/cjoc201809031 Previous Articles     Next Articles



张健a, 刘园园b, 冯维春c, 武玉民a   

  1. a 青岛科技大学化工学院 青岛 266042;
    b 青岛科技大学化学与分子工程学院 青岛 266042;
    c 青岛科技大学山东化工研究院 济南 250014
  • 收稿日期:2018-09-26 修回日期:2018-11-06 发布日期:2018-12-17
  • 通讯作者: 张健
  • 基金资助:


Recent Progress in Beckmann Rearrangement

Zhang Jiana, Liu Yuanyuanbb, Feng Weichuncc, Wu Yumina   

  1. a College of Chemical Engineering, Qingdao University of Science & Technology, Qingdao 266042;
    b College of Chemistry & Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042;
    c Chemical Technology Academy of Shandong Province, Qingdao University of Science & Technology, Qingdao 250014
  • Received:2018-09-26 Revised:2018-11-06 Published:2018-12-17
  • Contact: 10.6023/cjoc201809031
  • Supported by:

    Project supported by the Science and Technology Development Project in University of Shandong Province (No.J18KA102),the Natural Science Foundation of Shandong Province of China (No.ZR201807060818).

Amide motifs are prevalent structures found in natural products, pharmaceuticals, and bioactive compounds. Amide bond formations are the most important transformations in organic chemistry. Beckmann rearrangement is a significant method for the synthesis of primary and secondary amides. Recently, diversified new catalytic protocols were developed, including one-pot reaction from the corresponding aldehydes and ketones, or even from alcohols. The progress and applications of Beckmann rearrangement in recent five years are reviewed.

Key words: Beckmann rearrangement, amides, synthesis, oximes