Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (10): 2771-2785.DOI: 10.6023/cjoc201904061 Previous Articles     Next Articles

Special Issue: 荧光探针-生物传感合辑 有机超分子化学合辑



王能a, ManiArulkumara, 陈孝云b*(), 王柏文a, 陈思鸿a, 姚辰a, 汪朝阳a*()   

  1. a 华南师范大学化学学院 教育部环境理论化学重点实验室 广州市生物医药分析化学重点实验室 广州 510006
    b 江苏科技大学环境与化学工程学院 镇江 212003
  • 收稿日期:2019-04-25 修回日期:2019-05-14 发布日期:2019-06-03
  • 通讯作者: 陈孝云,汪朝阳;
  • 基金资助:

Research Progress in Design, Synthesis and Application of Benzo Nitrogen-Containing Heterocyclic Fluorescent Probes

Wang Nenga, Arulkumar Mania, Chen Xiaoyunb*(), Wang Bowena, Chen Sihonga, Yao Chena, Wang Zhaoyanga*()   

  1. a Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006
    b School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003
  • Received:2019-04-25 Revised:2019-05-14 Published:2019-06-03
  • Contact: Chen Xiaoyun,Wang Zhaoyang;
  • Supported by:
    Project supported by the National Natural Science Foundation of China(21602085);The Natural Science Foundation of Guangdong Province(2014A030313429);The Guangzhou Science and Technology Project Scientific Special(201607010251);The Natural Science Foundation of Jiangsu Province(BK20160551);The Guangdong Provincial Science and Technology Project(2017A010103016);The Undergraduates Innovation Project of South China Normal University(20191434)

Benzo five-/six-membered nitrogen-containing heterocyclic compound with a rigid plane and a large conjugate structure can emit characteristic fluorescence in a variety of organic solvents and mixed solutions, and N, O, S heteroatoms in the structure can serve as binding sites for fluorescent probes. Therefore, in recent years, benzo nitrogen-containing heterocyclic compounds are increasingly becoming one of the research focuses in the field of fluorescent probes. From the perspective of starting materials, synthesis methods, molecular structure, interaction mechanism, benzo five- / six-membered nitrogen-containing heterocyclic fluorescent probes containing the structure of benzoxazole, benzothiazole, benzimidazole, indole, carbazole, quinoline, benzopyrazine and phenazine are introduced with emphasis. And their detection application for a variety of analytes, such small molecules, metal cations, anions and pH are reviewed. In the future, it is worthy of further attention to the research on the integration of multiple heterocyclic functional structures into a multifunctional fluorescent probe by simple and green synthesis.

Key words: benzo five-membered nitrogen heterocycle, benzo six-membered nitrogen heterocycle, fluorescent probe, design and synthesis, recognition mechanism, detection application, multifunctionalization