Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (12): 3414-3437.DOI: 10.6023/cjoc201906015 Previous Articles     Next Articles

以苝二酰亚胺为发色团的荧光探针的研究进展

石岩a, 于有伟a, 薛林b, 王延风b   

  1. a 山西师范大学食品科学学院 临汾 041004;
    b 山东省医学科学院药物研究所 济南 250062
  • 收稿日期:2019-06-13 修回日期:2019-07-05 出版日期:2019-12-25 发布日期:2019-07-24
  • 通讯作者: 石岩, 王延风 E-mail:wyfshiwoya@126.com;shiyansdu@163.com
  • 基金资助:
    国家自然科学基金(No.21305079)资助项目.

Progress of Fluorescent Probes with Perylene Tetracarboxylic Diimide as Chromophore

Shi Yana, Yu Youweia, Xue Linb, Wang Yanfengb   

  1. a Collge of Food Sciences, Shanxi Normal University, Linfen, Shanxi 041004;
    b Institute of Materia Medica Shandong Academy of Medical Sciences, Jinan 250062
  • Received:2019-06-13 Revised:2019-07-05 Online:2019-12-25 Published:2019-07-24
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21305079).

In recent years, molecular fluorescent probes have attracted extensive attention due to their high sensitivity, high selectivity, specificity and simplicity of design. Perylene tetracarboxylic diimide derivatives (PDIs) are well known for their excellent photothermal stability, chemical stability, high fluorescence quantum yield, large stokes shift and easy modification. Therefore, they can be used as excellent fluorophores. PDI itself has strong electron-withdrawing group and easily to be reduced but it is hard to be oxidized. However, due to their inherent structure, the poor water solubility and aggregatable ablility limited their applications in biological fields. The water solubility of PDI was improved by introducing hydrophilic groups into the structure. Therefore, the PDIs with the unique advantages will have potential application values in the field of fluorescence probe and has been developed rapidly for the past few years. The development of PDI as a chromophore in fluorescent probe for the detection of ion, gas, biomolecules, etc. is systematically summarized. Meanwhile, the design of the probes, fluorescence response mechanism and application of the probe are also discussed. Finally, a novel type of PDI fluorescent probe is proposed. The challenge of construction of the PDIs and future development are also reviewed.

Key words: perylene tetracarboxylic diimide, fluorescent probe, ion-detection, gas detection, biomolecules detection