Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (12): 3375-3383.DOI: 10.6023/cjoc201906029 Previous Articles     Next Articles

检测一氧化碳分子荧光探针的研究进展

魏超, 张平竹, 李小六   

  1. 河北大学化学与环境科学学院 河北省化学生物学重点实验室 药物化学与分子诊断教育部重点实验室 河北保定 071002
  • 收稿日期:2019-06-24 修回日期:2019-07-18 出版日期:2019-12-25 发布日期:2019-08-07
  • 通讯作者: 魏超, 李小六 E-mail:weichao@hbu.edu.cn;lixl@hbu.cn.
  • 基金资助:
    国家自然科学基金(No.21778013)、河北省自然科学基金(No.B2018201234)和河北省高等学校科学技术研究(No.QN2017015)资助项目.

Progress in Fluorescent Probes for Carbon Monoxide Detecting

Wei Chao, Zhang Pingzhu, Li Xiaoliu   

  1. Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding, Hebei 071002
  • Received:2019-06-24 Revised:2019-07-18 Online:2019-12-25 Published:2019-08-07
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21778013), the Natural Science Foundation of Hebei Provience (No. B2018201234), and the Colleges and Universities Science Technology Research Project of Hebei Province (No. QN2017015).

As an important endogenous gas transmitter, carbon monoxide (CO) has been found taking part in multiple physiological and pathological processes for life. Therefore, the selective recognition and sensitive detection of CO are of great biological and medical significance. Fluorescent probe method is highlighted by its good selectivity, high sensitivity, suitable for high-throughput screening, especially noninvasive detection, and real-time monitoring in situ. Therefore, the development of fluorescent probes for intracellular CO has been becoming one of the hot topics. Herein, the progress during the last decade of fluorescent molecular probes based on the small molecules for CO detection is reviewed. These fluorescent probes are classified and concluded according to the design concepts, detection mechanism, and biological applications. In addition, the relationship between molecular structures and properties is elucidated. Finally, the challenge and application prospects for the development of CO fluorescent probes are also discussed.

Key words: carbon monoxide, gasotransmitter, fluorescent probe, fluorescent imaging