Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (1): 232-238.DOI: 10.6023/cjoc201908006 Previous Articles     Next Articles

含1,3,4-噁二唑结构的新型吡唑肟醚类衍生物的合成及杀虫活性

王杨a, 叶浩a, 钱程a, 姚炜a, 李宏b, 王凯a, 胡兰萍a, 李玲a, 吴锦明a, 戴红a   

  1. a 南通大学化学化工学院 南通 226019;
    b 南通丰田化工有限公司 南通 226005
  • 收稿日期:2019-08-04 修回日期:2019-08-26 出版日期:2020-01-25 发布日期:2019-09-05
  • 通讯作者: 胡兰萍, 戴红 E-mail:hlp@ntu.edu.cn;daihong_2015@aliyun.com
  • 基金资助:
    国家自然科学基金(No.21372135)、南通市科技计划(No.MS12017022-4,MS12019060)和和江苏省大学生创新训练计划(No.201810304016Z)资助项目.

Synthesis and Insecticidal Activities of Novel Pyrazole Oxime Ethers Carrying 1,3,4-Oxadiazole Unit

Wang Yanga, Ye Haoa, Qian Chenga, Yao Weia, Li Hongb, Wang Kaia, Hu Lanpinga, Li Linga, Wu Jinminga, Dai Honga   

  1. a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
    b Nantong Fengtian Chemical Industry Co. Ltd, Nantong 226005
  • Received:2019-08-04 Revised:2019-08-26 Online:2020-01-25 Published:2019-09-05
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21372135), the Science and Technology Project Fund of Nantong City (No. MS12017022-4, MS12019060), and the Science and Technology Innovation Foundation for the College Students of Jiangsu Province (No. 201810304016Z).

In search of novel pyrazole oxime ether derivatives with potent bioactivities, fifteen new pyrazole oxime ethers were designed and synthesized by introducing 1,3,4-oxadiazole moiety into the C-4 position of pyrazole based on the structure of fenpyroximate. Their structures were confirmed by 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay data showed that some title compounds possessed good insecticidal activities against Oriental armyworm or Aphis medicaginis at the concentration of 500 and 100 μg/mL. At 100 μg/mL, compounds 10a, 10e, 10f and 10j displayed 100% mortality rate against Oriental armyworm, and compounds 10g, 10j and 10l showed insecticidal activity against Aphis medicaginis with 100%. In addition, compound 10l had 100% mortality rate against Tetranychus cinnabarinus at 500 μg/mL.

Key words: 1,3,4-oxadiazole, pyrazole oxime ether, synthesis, insecticidal activity