Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 2114-2119.DOI: 10.6023/cjoc202002008 Previous Articles     Next Articles


牛伟, 肖丹, 程航, 徐亮   

  1. 四川大学华西药学院 天然药物系暨教育部靶向药物重点实验室 成都 610041
  • 收稿日期:2020-02-07 修回日期:2020-04-21 发布日期:2020-05-11
  • 通讯作者: 徐亮
  • 基金资助:

Synthesis of 6α- and 6β-Hydroxydeoxycholic Acid

Niu Wei, Xiao Dan, Cheng Hang, Xu Liang   

  1. Key Laboratory of Drug Targeting, Ministry of Education, Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu 610041
  • Received:2020-02-07 Revised:2020-04-21 Published:2020-05-11
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21871190).

6α- and 6β-hydroxydeoxycholic acids[DCA-6α-ol (6) and DCA-6β-ol (7)] are recently identified important tertiary bile acids derived from deoxycholic acid (3) in human liver. A rapid and robust synthesis of DCA-6α-ol (6) and DCA-6β-ol (7) from cholic acid (1) in 10 steps involing the key Mukaiyama aldol condensation, ozone oxidative cleavage and SmI2 promoted reductive deoxygenation was conducted.

Key words: bile acid, 6α-hydroxydeoxycholic acid, 6β-hydroxydeoxycholic acid, synthesis