Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 1941-1947.DOI: 10.6023/cjoc202003034 Previous Articles     Next Articles


程晓红a, 李爽b, 汪竞阳a, 李望南a   

  1. a 湖北文理学院 低维光电材料与器件湖北省重点实验室 湖北襄阳 441053;
    b 湖北航天化学技术研究所 湖北襄阳 441003
  • 收稿日期:2020-03-13 修回日期:2020-04-12 发布日期:2020-05-11
  • 通讯作者: 程晓红
  • 基金资助:

“Turn-On” Fluorescent Probe for Hypochlorite: Successful Bioimaging and Real Application in Tap Water

Cheng Xiaohonga, Li Shuangb, Wang Jingyanga, Li Wangnana   

  1. a Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices, Hubei University of Arts and Science, Xiangyang, Hubei 441053;
    b Hubei Institute of Aerospace Chemical Technology, Xiangyang, Hubei 441003
  • Received:2020-03-13 Revised:2020-04-12 Published:2020-05-11
  • Supported by:
    Project supported by the Natural Science Foundation of Hubei Province (No. 2018CFB454), the Project of Hubei University of Arts and Science (No. XK2020042) and the Teachers' Scientific Ability Cultivation Foundation of Hubei University of Arts and Science (No. 2020kypyfy031).

Taking advantage of the special oxidation property of hypochlorite, two novel coumarin-type fluorescent probes C1 and C2 were synthesized for ClO- detection. Both probes could detect ClO- anions in aqueous solution efficiently with rapid switching-on fluorescent methods. Especially, probe C2 displayed dramatic enhancement in fluorescence emission spectra with the detection limit of 1.8×10-7 mol/L. In addition to its high selectivity for ClO- rather than other common anions and reactive oxygen species, C2 was successfully applied to the bioimaging in HeLa cells with ‘turn-on’ fluorescent methods. Moreover, probe C2 could be used for the analysis of ClO- levels in tap water and potentially in environmental samples.

Key words: fluorescent probe, hypochlorite, good solubility, bioimaging application