Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (3): 1002-1011.DOI: 10.6023/cjoc202007051 Previous Articles     Next Articles



刘玎a,b, 朱园园c, 古双喜a,b,*(), 陈芬儿a,b,d,*()   

  1. a 武汉工程大学化工与制药学院 绿色化工过程教育部重点实验室 武汉 430205
    b 武汉工程大学药物研究院 武汉 430205
    c 武汉工程大学化学与环境工程学院 武汉 430205
    d 复旦大学化学系 上海 200433
  • 收稿日期:2020-07-22 修回日期:2020-09-14 发布日期:2020-10-12
  • 通讯作者: 古双喜, 陈芬儿
  • 基金资助:
    国家自然科学基金(21877087); 国家自然科学基金(21602164); 新型反应器与绿色化学工艺湖北省重点实验室(武汉工程大学)开放基金(K202004)

Application of Flow Chemistry in Halogenation

Ding Liua,b, Yuanyuan Zhuc, Shuangxi Gua,b,*(), Fener Chena,b,d,*()   

  1. a Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy,Wuhan Institute of Technology, Wuhan 430205
    b Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan 430205
    c School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205
    d Department of Chemistry, Fudan University, Shanghai 200433
  • Received:2020-07-22 Revised:2020-09-14 Published:2020-10-12
  • Contact: Shuangxi Gu, Fener Chen
  • About author:
    * Corresponding authors. E-mail: ;
  • Supported by:
    National Natural Science Foundation of China(21877087); National Natural Science Foundation of China(21602164); Open Fund of Hubei Key Laboratory of Novel Reactor and Green Chemical Technology (Wuhan Institute of Technology)(K202004)

The halogenation of organic compounds is one of the most important transformations in organic synthesis. However, there are some problems in traditional batch halogenation, such as high exothermicity, poor selectivity and the use of highly toxic and corrosive halogenating agents. Flow chemistry has its unique advantages such as high mixing efficiency, fast heat and mass transfer performance, accurate control over process parameters and enhanced process safety, reduced energy input and so on. According to the classification of halogenation of organic compounds, the main progress of flow chemistry in fluorination, chlorination, bromination and iodization is summarized systematically, and its development trend is prospected.

Key words: flow chemistry, microreactor, continuous flow, halogenation, organic synthesis