Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (10): 3965-3982.DOI: 10.6023/cjoc202104008 Previous Articles     Next Articles

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C-3位五元螺环吲哚酮衍生物合成方法研究进展

刘奕彤a, 张茜苑a, 苗志伟a,b,*()   

  1. a 南开大学化学学院 元素有机化学国家重点实验室 天津 300071
    b 天津化学化工协同创新中心 天津 300071
  • 收稿日期:2021-04-04 修回日期:2021-05-03 发布日期:2021-06-02
  • 通讯作者: 苗志伟
  • 基金资助:
    国家自然科学基金(22071113); 天津市重点研发计划(19YFZCSN00240)

Research Progress on the Synthetic Method of Five-Membered Spirooxindole Derivatives at C-3 Position

Yitong Liua, Xiyuan Zhanga, Zhiwei Miaoa,b()   

  1. a Research Institute of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071
    b Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071
  • Received:2021-04-04 Revised:2021-05-03 Published:2021-06-02
  • Contact: Zhiwei Miao
  • Supported by:
    National Natural Science Foundation of China(22071113); Key Technologies R & D Program of Tianjin City(19YFZCSN00240)

As the core skeleton structure of many drugs and natural products, spirooxindole derivatives have a wide range of applications in the field of biology and medicine. Efficient synthesis of spirooxindole derivatives with high enantioselectivity and diastereoselectivity has gained much attention in organic chemical community. In this paper, the asymmetric synthetic methods for C-3 five-membered spirooxindoles by catalytic intramolecular reactions, intermolecular reactions and three- component reactions are reviewed. The future development direction of this field is also prospected.

Key words: spirooxindoles, synthetic method, asymmetric synthesis