Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (10): 3808-3815.DOI: 10.6023/cjoc202105057 Previous Articles     Next Articles



王耀鑫, 崔晨, 杨小会*()   

  1. 北京理工大学前沿交叉科学研究院 化学与化工学院 北京 100081
  • 收稿日期:2021-05-31 修回日期:2021-07-15 发布日期:2021-09-17
  • 通讯作者: 杨小会

Recent Advances in Hydrochlorination of Alkenes

Yaoxin Wang, Chen Cui, Xiaohui Yang()   

  1. Advanced Research Institute of Multidisciplinary Science, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081
  • Received:2021-05-31 Revised:2021-07-15 Published:2021-09-17
  • Contact: Xiaohui Yang

Organochlorides have been widely used in medicine, pesticides, materials and other fields. In addition, organochlorides are also important synthetic building blocks. They have participated in a variety of reactions, such as free radical reactions, substitution reactions and cross-coupling reactions. The hydrochlorination of olefins is one of the most direct and efficient methods for the synthesis of organochlorides, and remakable breakthroughs have been made in the past thirty years. The research progress of olefin hydrochlorination in the past three decades is introduced. According to whether metal catalysis is involved, it is mainly classified into two categories: metal-free alkene hydrochlorination and metal-catalyzed alkene hydrochlorination. Different type of hydrochlorination reactions and related mechanisms are summarized. In addition, the future development direction of alkene hydrochlorination is prospected.

Key words: alkene, hydrochlorination, hydrogen chloride, organochloride, metal catalysis