Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (6): 1952-1962.DOI: 10.6023/cjoc202210030 Previous Articles     Next Articles


李宜芳a, 王耀a,*(), 牛华伟a,*(), 陈秀金a, 李兆周a, 王永国b   

  1. a 河南科技大学食品与生物工程学院/河南省食品绿色加工与质量安全控制国际联合实验室 河南洛阳 471000
    b 安阳学院 河南安阳 455000
  • 收稿日期:2022-10-24 修回日期:2023-01-21 发布日期:2023-02-14
  • 基金资助:
    国家自然科学基金(31702218); 河南省青年人才托举工程(2020HYTP029); 河南省研究生教育改革与质量提升工程(HNYJS2020JD06); 河南省科技攻关(232102320298); 河南省科技攻关(222102310524)

Research Progress of Sulfur Dioxide Fluorescent Probe Targeting Mitochondria

Yifang Lia, Yao Wanga,*(), Huawei Niua,*(), Xiujin Chena, Zhaozhou Lia, Yongguo Wangb   

  1. a College of Food & Bioengineering, Henan University of Science and Technology/Henan International Joint Laboratory of Food Green Processing and Quality Safety Control, Luoyang, Henan 471000
    b Anyang University, Anyang, Henan 455000
  • Received:2022-10-24 Revised:2023-01-21 Published:2023-02-14
  • Contact: E-mail:;
  • Supported by:
    National Natural Science Foundation of China(31702218); Youth Talent Support Project of Henan Province(2020HYTP029); Postgraduate Education Reform and Quality Improvement Project of Henan Province(HNYJS2020JD06); Scientific and Technological Research Project of Henan Province(232102320298); Scientific and Technological Research Project of Henan Province(222102310524)

Content of abstract sulfur dioxide (SO2) is associated with many physiological and pathological processes in living systems, and excessive SO2 can lead to a series of physiological diseases. Therefore, effective identification and detection of SO2 have significant application value. Recently, many fluorescent probes for the detection of SO2 in biological systems have been reported. Compared with traditional detection methods, fluorescent probe has the advantages of high sensitivity, non-invasive detection and real-time imaging. More importantly, the use of fluorescent probes allows visual detection of SO2 both in vitro and in vivo. Based on different reaction mechanism, the research progress of mitochondrial targeted SO2 fluorescent probes in the past five years is reviewed, and the challenges and development directions in this field are discussed.

Key words: mitochondria, fluorescent probe, sulfur dioxide, cell imaging