Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (01): 77-81. Previous Articles     Next Articles

Original Articles

含肉桂酰胺类化合物的合成及α-糖苷酶抑制活性

蔡小华*,a,b,吴英华a   

  1. (a怀化医学高等专科学校药学系 怀化 418000)
    (b贵州民族学院化学与环境科学学院 贵阳 550025)
  • 收稿日期:2006-02-27 修回日期:1900-01-01 发布日期:2006-12-30
  • 通讯作者: 蔡小华

Synthesis and α-Glucosidase Inhibitory Activity of Cinnamic Amides

CAI Xiao-Hua*,a,b,WU Ying-Huaa   

  1. (a Department of Pharmacy, Huaihua Medical College, Huaihua 418000)
    (b College of Chemistry and Environmental Science, Guizhou University for Nationalities, Guiyang 550025)
  • Received:2006-02-27 Revised:1900-01-01 Published:2006-12-30
  • Contact: CAI Xiao-Hua

Four new cinnamic amides 9a9d were synthesized, and their preliminarily inhibitory activities for α-glucosidase were evaluated. All of these compounds displayed inhibitory activities of α-glucosidase, and are a new structural type of α-glucosidase inhibitory compounds. The inhibitory activity of 9b and 9d was higher than those of control drug acarbose.

Key words: cinnamic amide, synthesis, α-glucosidase inhibitory activity, diabetes