Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (03): 339-346. Previous Articles     Next Articles

Review

奥斯米韦合成进展

贺丽敏,胡艾希*,董敏宇,夏林   

  1. (湖南大学化学化工学院 长沙 410082)
  • 收稿日期:2006-02-27 修回日期:1900-01-01 发布日期:2007-02-13
  • 通讯作者: 胡艾希

Progress in Oseltamivir Synthesis

HE Li-Min,HU Ai-Xi*,DONG Min-Yu,XIA Lin   

  1. (College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082)
  • Received:2006-02-27 Revised:1900-01-01 Published:2007-02-13
  • Contact: HU Ai-Xi

This paper summarizes the synthetic methods of inhibitors of neuraminidase oseltamivir. It includeds the chiral synthesis route from (−)-quinic acid, (−)-shikimic acid and D-mannose, the synthesis route from benzene or benzoic acid and the synthesis route based on the Diels-Alder reaction.

Key words: oseltamivir, synthesis, progress, neuraminidase inhibitor