Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (10): 1797-1802. Previous Articles     Next Articles



杨兰义a ; 张殊佳a,b; 郑学仿*,b; 尹红星a   

  1. (a大连大学环境与化学工程学院 大连 116622)
    (b辽宁省生物有机化学重点实验室 大连 116622)
  • 收稿日期:2008-03-08 修回日期:2008-05-05 发布日期:2008-10-20
  • 通讯作者: 郑学仿

Synthesis of β-Elemene Glycoside Derivatives

YANG, Lan-Yia ; ZHANG, Shu-Jia a,b ; ZHENG, Xue-Fang*,b ; YIN, Hong-Xinga   

  1. (a College of Environmental and Chemical Engineering, Dalian University, Dalian 116622)
    (b Key Laboratory of Bioorganic Chemistry of Liaoning Province, Dalian 116622)
  • Received:2008-03-08 Revised:2008-05-05 Published:2008-10-20
  • Contact: ZHENG, Xue-Fang

Structural modification of β-elemene was reported. Treatment of its 13-chloride 2 with anhydrous sodium acetate gave ester 3, which was converted into β-elemene-13-ol (4) by hydrolization. Whereafter, 4 was conjugated with a series of representative monosaccharides or disaccharides and corresponding β-glycosides 9a~9e were selectively synthesized following two approaches in satisfactory yields. The structures of products were confirmed on the basis of IR, 1H NMR, 13C NMR and HRMS data.

Key words: derivative, β-elemene, glycoside, synthesis