Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (07): 1142-1146. Previous Articles     Next Articles

Reports

手性Salen(Co)(OAc)催化胺解动力学拆分外消旋末端的环氧化物

王朝阳; 宋光伟; 朱锦桃*   

  1. (浙江理工大学化学系 杭州 310018)
  • 收稿日期:2008-09-13 修回日期:2008-11-29 出版日期:2009-07-22 发布日期:2009-07-22
  • 通讯作者: 朱锦桃

Efficient Kinetic Resolution of Terminal Epoxides with Phthalimide Using Chiral Salen(Co)(OAc)

Wang, Chaoyang; Song, Guangwei ; Zhu, Jintao*   

  1. (Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018)
  • Received:2008-09-13 Revised:2008-11-29 Online:2009-07-22 Published:2009-07-22
  • Contact: Zhu, Jintao

The example of enantioselective kinetic resolution (KR) of racemic terminal epoxides using phthalimide as the nucleophile catalyzed by chiral salen(Co)(OAc) is described. The process afforded enantiopure epoxides and enantioenrich N-protected 1,2-amino alcohol in moderate ee value. Using an easily accessible catalyst and inexpensive staring materials, the reaction was conveniently carried out without protected atmosphere.

Key words: phthalimide, terminal epoxide, chiral salen(Co)(OAc), kinetic resolution