Synthesis and Fungicidal Activity of Diamide Compounds Based on the Metabolite of Benalaxyl

doi:10.6023/cjoc201608006

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (1): 157-165.DOI: 10.6023/cjoc201608006 Previous Articles Next Articles

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基于苯霜灵代谢物结构的双酰胺化合物的合成与杀菌活性研究

孙国绍, 王玲娜, 金淑惠, 董燕红, 路慧哲, 张建军

中国农业大学理学院北京 100193

收稿日期:2016-08-10 修回日期:2016-08-31 发布日期:2016-09-08
通讯作者: 金淑惠, 张建军 E-mail:shuhuij@cau.edu.cn;zhangjianjun@cau.edu.cn
基金资助:
国家基础科学人才培养基金（No. J1210064）及国家自然科学基金（No. 21337005）资助项目.

Synthesis and Fungicidal Activity of Diamide Compounds Based on the Metabolite of Benalaxyl

Sun Guoshao, Wang Lingna, Jin Shuhui, Dong Yanhong, Lu Huizhe, Zhang Jianjun

China Agricultural University, Beijing 100193

Received:2016-08-10 Revised:2016-08-31 Published:2016-09-08
Supported by:
Project supported by National Science Foundation for Fostering Talents in Basic Research of China(No. J1210064) and the National Natural Science Fondation of China(No. 21337005).

Based on benalaxyl pesticide metabolite structure framework,fourteen novel diamide derivatives were synthesized by the reaction of amine and N₂-carboxyacetyl-N₁-(2,6-dimethylphenyl) alanine methyl ester.Their structures were identified by ¹H NMR,¹³C NMR spectra and HRMS.The results of bioassay indicated that some compounds possess potential fungicidal activities against 8 kinds of bacteria,and the antibacterial activity of some compounds was better than that of benalaxyl.At a dosage of 5.0×10^-5 g/mL,compound 7d displayed 94.2% antifungal activities against Rhizoctonia solani.Compound 8f displayed 87.1% and 88.9% antifungal activities against Phytophthora capsici and Rhizoctonia solani.

Key words: benalaxyl, metabolite, diamide, synthesis, antifungal activity

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Sun Guoshao, Wang Lingna, Jin Shuhui, Dong Yanhong, Lu Huizhe, Zhang Jianjun. Synthesis and Fungicidal Activity of Diamide Compounds Based on the Metabolite of Benalaxyl[J]. Chin. J. Org. Chem., 2017, 37(1): 157-165.

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基于苯霜灵代谢物结构的双酰胺化合物的合成与杀菌活性研究

Synthesis and Fungicidal Activity of Diamide Compounds Based on the Metabolite of Benalaxyl

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