Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (3): 617-623.DOI: 10.6023/cjoc201610014 Previous Articles     Next Articles



高勇a,b, 汪军a, 付妹a, 陈宏伟a, 方明章a   

  1. a 福建师范大学化学与化工学院 福州 350007;
    b 福建师范大学 福建省先进材料化工基础重点实验室 福州 350007
  • 收稿日期:2016-10-11 修回日期:2016-12-15 发布日期:2016-12-29
  • 通讯作者: 高勇,
  • 基金资助:


A Water-Soluble Rhodamine-Based Fluorescent Probe for Fe3+ and Its Application in Live Cell Imaging

Gao Yonga,b, Wang Juna, Fu Meia, Chen Hongweia, Fang Mingzhanga   

  1. a College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou 350007;
    b Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, Fujian Normal University, Fuzhou 350007
  • Received:2016-10-11 Revised:2016-12-15 Published:2016-12-29
  • Contact: 10.6023/cjoc201610014
  • Supported by:

    Project supported by the Natural Science Foundation of Fujian Province (No. 2013H0019).

A rhodamine-based water-soluble fluorescent probe of Fe3+(T1) was designed and synthesized, in which a carboxy was linked to enhance its water solubility. Its structure was characterized by 1H NMR, 13C NMR and HRMS-ESI. The fluorescent probe showed remarkable "turn-on" fluorescent responses to Fe3+ with good selectivity over other competitive cations. It has a good water solubility that the recognition properties of the probe with Fe3+ ions can be investigated in DMF/Tris-HCl (V:V=1:9, pH=7.4). The fluorescence imaging experiments of Fe3+ in MCF-7 living cells demonstrated that the probe had a good cell-membrane permeability and it could be used in biological systems.

Key words: rhodamine, water solubility, Fe3+, fluorescent probe, live cell imaging