Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (8): 2044-2049.DOI: 10.6023/cjoc201702003 Previous Articles     Next Articles

Special Issue: 高被引论文合辑(2017-2018)

ARTICLE

新型吡唑酰基脲类化合物的设计合成、杀菌活性与分子对接研究

孙娜波a, 沈钟华b, 翟志文b, 武宏科b, 翁建全b, 谭成侠b, 刘幸海b   

  1. a 浙江树人大学生物与环境学院 杭州 310015;
    b 浙江工业大学化学工程学院 杭州 310014
  • 收稿日期:2017-02-03 修回日期:2017-03-30 出版日期:2017-08-25 发布日期:2017-04-18
  • 通讯作者: 刘幸海 E-mail:xhliu@zjut.edu.cn
  • 基金资助:

    国家自然科学基金(No.31401691)和浙江省自然科学基金(No.LY16C14007)资助项目.

Design, Synthesis, Fungicidal Activity and Docking Study of Acyl Urea Derivatives Containing Pyrazole Moiety

Sun Naboa, Shen Zhonghub, Zhai Zhiwenb, Wu Hongkeb, Weng Jianquanb, Tan Chengxiab, Liu Xinghaib   

  1. a College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015;
    b College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2017-02-03 Revised:2017-03-30 Online:2017-08-25 Published:2017-04-18
  • Contact: 10.6023/cjoc201702003 E-mail:xhliu@zjut.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 31401691) and the Zhejiang Provincial Natural Science Foundation of China (No. LY16C14007).

A series of novel acyl urea derivatives containing pyrazole moiety were synthesized from ethyl acetoacetate, triethyl orthoformate, methylhydrazine by multi-step reactions. Their structures were characterized by 1H NMR and HRMS spectra. The target compounds were evaluated for their fungicidal activity. The results indicated that some of the title compounds displayed certain fungicidal activities against Cercospora arachidicola, Sclerotinia sclerotiorum, Rhizoctonia solani and Physalopora piricola. The docking results indicated the hydrogen bond formed between the amide group and Ser 39 residue.

Key words: pyrazole, acyl urea, synthesis, fungicidal activity, docking