Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (12): 3112-3129.DOI: 10.6023/cjoc201706006 Previous Articles     Next Articles



丁怀伟, 李娟, 郭庆辉, 肖琰   

  1. 沈阳药科大学 基于靶点的药物设计与研究教育部重点实验室 沈阳 110016
  • 收稿日期:2017-06-04 修回日期:2017-07-28 发布日期:2017-08-16
  • 通讯作者: 肖琰
  • 基金资助:


Research Progress on Transition-Metal-Catalyzed C-H Activation/C-O Coupling Reaction of Arenes

Ding Huaiwei, Li Juan, Guo Qinghui, Xiao Yan   

  1. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016
  • Received:2017-06-04 Revised:2017-07-28 Published:2017-08-16
  • Contact: 10.6023/cjoc201706006
  • Supported by:

    Project supported by the Natural Science Foundation of Liaoning Province (No. 2015020745).

Transition metal catalyzed C-H activation/C-O coupling reaction of arenes serves as a powerful strategy for constructing phenols, aryl ethers and phenolic esters, and thus represents a hot topic in the field of organic chemistry. This strategy is effective and atom-economic as it allows people to construct C-O bond directly from arenes, avoiding pre-functionalization of arenes. Recent development on transition metal catalyzed C-H activation/C-O coupling reactions according to different species of transition metal catalysts is summarized. Possible mechanisms of typical protocols are explained and compared. Existing problems and limitations, and a brief outlook in this field is also presented.

Key words: C-H activation, C-O coupling, phenol, aryl ether, phenolic ester