Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (12): 3155-3162.DOI: 10.6023/cjoc201708020 Previous Articles     Next Articles



戴红a, 姚炜a, 孙思宇a, 李玲a, 施磊a, 钱宏炜a, 李春建b, 石健b, 石玉军a   

  1. a 南通大学化学化工学院 南通 226019;
    b 南通大学分析测试中心 南通 226019
  • 收稿日期:2017-08-10 修回日期:2017-09-05 发布日期:2017-09-19
  • 通讯作者: 施磊, 石玉军;
  • 基金资助:


Synthesis and Bioactivities of Novel Pyrazole Oxime Ethers Containing Substituted Pyrazolyl Group

Dai Honga, Yao Weia, Sun Siyua, Li Linga, Shi Leia, Qian Hongweia, Li Chunjianb, Shi Jianb, Shi Yujuna   

  1. a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
    b Analysis and Testing Center, Nantong University, Nantong 226019
  • Received:2017-08-10 Revised:2017-09-05 Published:2017-09-19
  • Contact: 10.6023/cjoc201708020;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), and the Postgraduate Research and Practice Innovation Program of Jiangsu Province (No. SJCX17_0640).

In order to find novel pyrazole oxime ethers with good bioactivities, a series of novel pyrazole oxime ether compounds containing substituted pyrazole moiety were designed and synthesized according to the method of active substructure combination. Their structures were characterized by 1H NMR,13C NMR, and elemental analysis. Preliminary bioassay displayed that most target compounds had good insecticidal activities. At the concentration of 500 μg/mL, sixteen compounds showed insecticidal activity against Oriental armyworm with 80%~100%, fourteen compounds exhibited insecticidal activity against Aphis medicaginis with 80%~100%, and twelve compounds showed insecticidal activity against Nilaparvata lugens with 70%~100%. When the dosage was lowered to 100 μg/mL, five compounds still possessed inhibitory effect against Aphis medicaginis with 50%~80%.

Key words: pyrazole, pyrazole oxime, synthesis, bioactivity