Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (10): 2553-2570.DOI: 10.6023/cjoc201801035 Previous Articles     Next Articles



毕吉利a, 马然松b, 杨金会c   

  1. a 宁夏大学教育学院 银川 750021;
    b 兰州大学功能有机分子化学国家重点实验室 兰州 730000;
    c 宁夏大学天然气转化国家重点实验室培育基地 银川 750021
  • 收稿日期:2018-01-25 修回日期:2018-04-02 发布日期:2018-06-07
  • 通讯作者: 毕吉利,;杨金会,;
  • 基金资助:


Synthesis of Chiral α-Amino Acid Derivatives by Asymmetric Addition of α-Imino Ester

Bi Jilia, Ma Ransongb, Yang Jinhuic   

  1. a College of Education, Ningxia University, Yinchuan 750021;
    b State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000;
    c State Key Laboratory Cultivition Base of Natural Gas Conwersion, Ningxia University, Yinchuan 750021
  • Received:2018-01-25 Revised:2018-04-02 Published:2018-06-07
  • Contact: 10.6023/cjoc201801035;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21362025).

The wide applications of chiral α-amino acid derivatives in the pharmaceutical and fine chemical industry field has greatly arisen the development of its synthetic methods. So far, asymmetric nucleophilic addition reaction of α-imino ester has been proven to be one of the most effective methods to synthesize chiral α-amino acid derivatives and has been focused by chemists in the field of asymmetric catalysis. The development of such method on the view of reaction types and different kinds of nucleophiles is described. Specifically, allylation reaction, arylation reactions, Mannich reactions, alkenylation reactions, alkynylation reactions and alkylation reactions are introduced, together with the associated reaction mechanisms and recent developments. Additionally, a prospect on this research field is given.

Key words: α-imino ester, chiral α-amino acid derivative, asymmetric, addition reaction References