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化学学报
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化学学报 ›› 1993, Vol. 51 ›› Issue (1): 85-89. 上一篇    下一篇

研究论文

催化转移氢化还原腈类化合物成胺

尤冬;周后元;王其灼   

  1. 中国药科大学药物化学研究室;国家医药管理局上海医药工业研究院
  • 发布日期:1993-01-15

Reduction of nitriles to amines by catalytic transfer hydrogenation

YOU DONG;ZHOU HOUYUAN;WANG QIZHUO   

  • Published:1993-01-15

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503

被引次数

2

本文报道了在碱性条件下, 用水合肼处理氯化镍(NiCl2.6H2O)得到活性镍催化剂, 不经分离直接用于催化转移氢化还原腈类化合物成胺。方法温和简便, 收率中等(35～82%)。α, β-不饱和腈还原时收率较低(12～17%)。

关键词: 胺, 还原, 还原反应, 腈, 水合肼, 氯化镍, 催化反应

A simple and convenient method for reduction of nitriles to amines was reported .in the presence of solium hydroxide, nickel chloride (NiCl2.6H2O) was reduced by hydrazine hydrate to deposit active nickle metal which , in turn , catalyzed the hydrogen transfer from hydrazine hydrate to nitriles, thus affording amines in moderate yields(35～82%). but the poor yieldsof amines (12～175)from α, β-unsaturated nitriles were obtained.

Key words: AMINES, REDUCTION, REDUCTION REACTION, NITRILE, HYDRAZINE HYDRATE, NICKEL CHLORIDE, CATALYTIC REACTION

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