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化学学报
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化学学报 ›› 2006, Vol. 64 ›› Issue (11): 1189-1194. 上一篇    下一篇

研究论文

维生素C溶液有氧降解动力学

史焱，詹先成*，吕太平，马烈，曹呈勇, 舒晓明，李成容，李琳丽，何宁   

  1. (靶向药物教育部重点实验室 四川大学华西药学院 成都 610041)
  • 投稿日期:2005-08-26 修回日期:2006-04-10 发布日期:2006-06-15
  • 通讯作者: 詹先成

Kinetic Studies on the Oxidative Degradation of Vitamin C Solution

SHI Yan, ZHAN Xian-Cheng*, LÜ Tai-Ping, MA Lie, CAO Cheng-Yong, SHU Xiao-Ming, LI Cheng-Rong, LI Lin-Li, HE Ning   

  1. (Key Laboratory of Drug Targeting of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041)
  • Received:2005-08-26 Revised:2006-04-10 Published:2006-06-15
  • Contact: ZHAN Xian-Cheng

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1492

被引次数

30 | 5

建立了一种恒温高压氧药物稳定性加速试验方法, 用这种方法可在较短的时间内求得药物氧化反应的动力学参数. 以10%维生素C溶液为例, 维生素C在有氧和无氧条件下均可降解, 总的降解速率常数kt由两部分构成: kt＝kan＋kae, kan为无氧降解速率常数, 可表达为kan＝Aan•exp(－Ea,an /RT); kae为有氧降解速率常数, 可表达为kae＝Aae•exp(－Ea,ae/ RT)• .

关键词: 恒温高压氧加速试验, 药物稳定性, 降解动力学, 氧, 维生素C

An isothermal experiment with high pressure oxygen was established. The stability of 10% vitamin C solution as a model drug was studied and the kinetics parameters were obtained in a short time with the newly established experimental method. Because vitamin C degrades in both anaerobic and aerobic conditions, the total rate constant kt can be expressed as: kt＝kan＋kae, where kan and kae are the anaerobic and aerobic degradation rate constants, respectively. The kan can be expressed as kan＝Aan•exp(－Ea,an/RT) according to Arrhenius equation, and the kae was found to be kae＝Aae•exp(－Ea,ae/RT)• in our experiments.

Key words: isothermal experiment with high pressure oxygen, drug stability, degradation kinetics, oxygen, vitamin C