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化学学报
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化学学报 ›› 2010, Vol. 68 ›› Issue (18): 1855-1863. 上一篇    下一篇

研究论文

温度和pH双重敏感荧光复合微凝胶制备和表征

胡炜，张颖   

  1. (应用表面与胶体化学教育部重点实验室 陕西师范大学化学与材料科学学院 西安 710062)
  • 投稿日期:2009-05-12 修回日期:2009-04-15 发布日期:2010-05-19
  • 通讯作者: 张颖 E-mail:zhangy@snnu.edu.cn
  • 基金资助:

    国家自然科学基金(20373039)；陕西省自然科学基金(2007E106)

Synthesis and Characterization of Fluorescent Composite Microgels with the Dual Thermo- and pH-sensitive

HU Wei, ZHANG Ying   

  1. (Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Materials Science, Shaanxi Normal University, Xi an 710062)
  • Received:2009-05-12 Revised:2009-04-15 Published:2010-05-19
  • Contact: Ying ZHANG E-mail:zhangy@snnu.edu.cn

PDF

2056

被引次数

10 | 4

通过反相悬浮聚合法制备N-异丙基丙烯酰胺(NIPAM)和甲基丙烯酸(MAA)的共聚微凝胶P(NIPAM-co-MAA), 以其为模板, 利用3-氨丙基三乙氧基硅烷(APTES)在碱性条件下的水解缩合反应, 制备得到了由氨基修饰的P(NIPAM-co- MAA)/SiO2高分子/无机复合微凝胶, 再通过异硫氰酸荧光素(FITC)与氨基的键和作用, 得到了具有核-壳结构的温度和pH双重敏感荧光复合微凝胶. 通过扫描电子显微镜(SEM)、傅立叶变换红外光谱(FT-IR)、热台偏光显微镜(POM)和共聚焦激光扫描显微镜(CLSM)等手段对复合微凝胶进行了结构和性质表征, 结果表明, 该复合微凝胶对温度和pH均具有良好的响应特性, 并在可见光激发下发出荧光.

关键词: 高分子微凝胶, 温度敏感, pH敏感, 荧光

N-Isopropylacrylamide (NIPAM) and methacrylic acid (MAA) copolymer microgels were prepared by the inverse suspension polymerization technique. Using P(NIPAM-co-MAA) copolymer microgels as the template, amino modified P(NIPAM-co-MAA)/SiO2 polymer/inorganic composite microgels were prepared by the hydrolysis and condensation of (3-aminopropyl)-triethoxysilane (APTES) under alkaline condition. Finally, dual thermo- and pH-sensitive fluorescent composite microgels with core-shell structures were obtained via the reaction between the fluorescein isothiocyanate (FITC) and amino group. The structures and properties of the prepared composite microgels were characterized by the scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), polarized optical microscopy (POM) with hot stage and laser scanning confocal microscope (CLSM). The results were demonstrated that the composite microgels exhibited good sensitivities both to the temperature and pH, as well as emitted fluorescence in visible light range.

Key words: polymer microgels, temperature-sensitive, pH-sensitive, fluorescent