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化学学报
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化学学报 ›› 2008, Vol. 66 ›› Issue (13): 1565-1571. 上一篇    下一篇

研究论文

钌(II)多吡啶配合物的合成、荧光性质及与脱氧核糖核酸DNA的 作用机制研究

王海滔 胡婷婷 张黔玲* 刘剑洪*
任祥忠 李翠华 王 芳 张培新   

  1. (School of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen 518060)
  • 投稿日期:2007-07-03 修回日期:2008-01-07 发布日期:2008-07-14
  • 通讯作者: 张黔玲

Synthesis, DNA-binding and Luminescent Properties of Polypyridyl Ruthenium(II) Complex

WANG, Hai-Tao HU, Ting-Ting ZHANG, Qian-Ling* LIU, Jian-Hong*
REN, Xiang-Zhong LI, Cui-Hua WANG, Fang ZHANG, Pei-Xin   

  1. The polypyridyl ligand with multi coordination sites ODCIP (ODCIP＝3,4-dichloroimi- dazo[4,5-f][1,10]phenanthroline) and its ruthenium(II) complex [Ru(bpy)2ODCIP]2＋ were synthesized and characterized by elemental analyses, IR, NMR and FAB-MS. The DNA-binding properties of complex [Ru(bpy)2ODCIP]2＋ were studied by absorption spectra, fluorescent spectra and viscosity methods. The coordination of [Ru(bpy)2ODCIP]2＋ with Co2＋ was also investigated. The results indicated that [Ru(bpy)2ODCIP]2＋ bound to DNA by part intercalation. The binuclear complex [Ru(bpy)2(ODCIP)Co]4＋ could be formed by [Ru(bpy)2ODCIP]2＋ and Co2＋, and it bound to DNA by intercalation. Furthermore, the luminescent properties of [Ru(bpy)2ODCIP]2＋ and [Ru(bpy)2(ODCIP)Co]4＋ were investigated by fluorescent spectra.
  • Received:2007-07-03 Revised:2008-01-07 Published:2008-07-14
  • Contact: ZHANG, Qian-Ling

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被引次数

22 | 7

设计合成含多个配位中心的多吡啶配体ODCIP (3,4-二氯基苯并咪唑并[4,5-f][1,10]邻菲咯啉)及其钌(II)多吡啶配合物[Ru(bpy)2ODCIP]2＋. 运用元素分析、红外光谱、核磁谱和质谱对配体及配合物进行结构表征. 利用紫外吸收光谱、荧光光谱和粘度法研究了[Ru(bpy)2ODCIP]2＋与DNA(脱氧核糖核酸)的作用机制、与Co2＋配位后与DNA的作用机制及其荧光变化情况. 结果表明[Ru(bpy)2ODCIP]2＋与DNA通过部分插入模式作用, [Ru(bpy)2ODCIP]2＋与Co2＋配位形成的双核配合物[Ru(bpy)2(ODCIP)Co]4＋也能与DNA插入结合. 进一步利用稳态荧光发射光谱、荧光淬灭实验等方法研究了单核配合物[Ru(bpy)2ODCIP]2＋和双核配合物[Ru(bpy)2(ODCIP)Co]4＋的荧光性质.

关键词: 脱氧核糖核酸DNA, 多吡啶钌配合物, 双核, 插入, 荧光

The polypyridyl ligand with multi coordination sites ODCIP (ODCIP=3,4-dichlcro– imidazo[4,5-f][1,10]phenanthroline) and its ruthenium(II) complex [Ru(bpy)2ODCIP]2+ were synthesized and characterized by IR and FAB-MS. The DNA-binding properties of complex [Ru(bpy)2ODCIP]2+ were studied by absorption spectra and fluorescent spectra. The results indicated that [Ru(bpy)2ODCIP]2+ bound to DNA by intercalation. The binuclear complex [Ru(bpy)2(ODCIP)Co]4+ could be formed by [Ru(bpy)2ODCIP]2+ and Co2+, and it also bound to DNA by intercalation. Furthermore, the luminescent properties of [Ru(bpy)2ODCIP]2+ and [Ru(bpy)2(ODCIP)Co]4+ were investigated by fluorescent spectra.

Key words: DNA (deoxyribonucleic acid), polypyridyl ruthenium(II) complex, binuclear, intercalation, luminescence