有机化学 ›› 2015, Vol. 35 ›› Issue (4): 927-933.DOI: 10.6023/cjoc201409020 上一篇    下一篇

研究简报

微波辐射下硅磺酸催化的香豆素并[4,3-d]吡唑并[3,4-b]吡啶的高效合成

王菊仙a, 林伟b, 刘洪涛c, 胡明华b, 冯贤b, 任金凤a, 黄志斌b, 史达清b   

  1. a 中国医学科学院 北京协和医学院 医药生物技术研究所 北京 100050;
    b 苏州大学材料与化学化工学部 江苏省有机合成重点实验室 苏州 215123;
    c 河北省人民医院药学部 石家庄 050051
  • 收稿日期:2014-09-09 修回日期:2014-10-31 发布日期:2014-11-28
  • 通讯作者: 王菊仙 E-mail:imbjxwang@gmail.com
  • 基金资助:

    国家自然科学基金(No. 81473098)资助项目.

An Efficient Synthesis of Coumarino[4,3-d]pyrazolo[3,4-b]-pyridine Derivatives Catalyzed by Silica Sulfuric Acid under Microwave Irradiation

Wang Juxiana, Lin Weib, Liu Hongtaoc, Hu Minghuab, Feng Xianb, Ren Jinfenga, Huang Zhibinb, Shi Daqingb   

  1. a Institute of Medical Biotechnology, Chinese Academy of Medical Sciences and Perking Union Medical College, Beijing 100050;
    b Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123;
    c Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050051
  • Received:2014-09-09 Revised:2014-10-31 Published:2014-11-28
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 81473098).

在硅磺酸催化下, 通过微波辐射的3-酰基香豆素与5-氨基吡唑的反应, 一步高产率地合成了一系列香豆素并[4,3-d]吡唑并[3,4-b]吡啶衍生物. 该方法具有反应时间短(20~30 min)、选择性好、产率高、操作简单和环境友好等优点. 产物的结构经红外光谱、核磁共振谱及高分辨质谱予以确定.

关键词: 香豆素并[4,3-d]吡唑并[3,4-b]吡啶, 硅磺酸, 微波辐射

A series of coumarino[4,3-d]pyrazolo[3,4-b]pyridine derivatives were synthesized by the reaction of 3-acylcoumarin with 5-aminopyrazole catalyzed by silica sulfuric acid under microwave irradiation. This method has the advantages of short reaction times (20~30 min), excellent selectivity, good yields, and simple operation as well as environmental friendly. The structures of the products were identified by IR, NMR, and HRMS spectra.

Key words: coumarino[4,3-d]pyrazolo[3,4-b]pyridine, silica sulfuric acid, microwave irradiation