有机化学 ›› 2016, Vol. 36 ›› Issue (5): 889-912.DOI: 10.6023/cjoc201511017 上一篇    下一篇

综述与进展

重氮参与的过渡金属催化C—H烷基化反应研究进展

王亮a, 李站a, 万康a, 瞿星a, 胡思前a, 王锋b   

  1. a. 江汉大学光电化学材料与器件教育部重点实验室 化学与环境工程学院 武汉 430056;
    b. 湖北工程学院化学与材料科学学院 孝感 432000
  • 收稿日期:2015-11-06 修回日期:2016-01-10 发布日期:2016-02-01
  • 通讯作者: 胡思前, 王锋 E-mail:hbeukj@126.com;wangliang@jhun.edu.cn
  • 基金资助:

    国家自然科学基金(No.21302064)、湖北省教育厅科学研究计划指导性(No.B2015231)资助项目.

Progress in Diazo Compounds Mediated Transition-Metal-Catalyzed C—H Alkylation

Wang Lianga, Li Zhanaa, Wan Kanga, Qu Xingaa, Hu Siqiana, Wang Fengb   

  1. a. Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, School of Chemical and Environmental Engineering, Jianghan University, Wuhan 430056;
    b. College of Chemistry and Materials Science, Hubei Engineering University, Xiaogan 432000
  • Received:2015-11-06 Revised:2016-01-10 Published:2016-02-01
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21302064) and the Scientific Research Project of Hubei Provincial Department of Education (No. B2015231).

重氮化合物是一类环境友好、高效的反应试剂,已经被广泛应用于金属卡宾C—H插入反应.近些年,重氮化合物在一种新型的催化模式下参与到过渡金属催化的C—H活化反应中,能够实现芳烃和杂芳烃C—H键的烷基化反应.综述了各种金属催化下重氮化合物参与的C—H烷基化反应,以及相关的环化反应的最新研究进展,主要介绍各反应的特点、反应机理和合成应用,并展望它的发展前景.

关键词: 重氮化合物, 过渡金属催化, C—H活化, 烷基化

Diazo compounds had been widely employed as a class of environment friendly and highly efficient coupling reagents in transition-metal-catalyzed C—H bonds insertion reactions. Recently, C—H alkylation of various arenes and heteroarenes has been achieved enormous successes using diazo compounds as the alkylation reagents under a new catalytic model. The recent progress in diazo compounds mediated transition-metal-catalyzed C—H alkylation and tandem C—H alkylation/cyclization is reviewed, including reaction mechanism and synthetic applications. Furthermore, the prospects of this reaction are also discussed.

Key words: diazo compounds, transition-metal-catalysis, C—H activation, alkyaltion