关键词: 异喹啉, N-乙基-4-哌啶酮, N-乙氧羰基-4-哌啶酮, 绿色合成

A facile and rapid synthesis of 8-aryl-5,7,7-tricyanoisoquinoline derivatives from the reaction of aromatic aldehydes, malononitrile, and N-substituted-4-piperidones at room temperature under solvent-free and catalyst-free conditions. The N-ethylpiperidin-4-one was first used for the synthesis of 6-amino-2-ethyl-8-aryl-2,3,8,8a-tetrahydroisoquinoline-5,7,7(1H)- tricarbonitrile derivatives. This method offers several advantages in terms of its mild conditions, available raw materials, simple operation, high yields, short reaction time and green process. The products were identified by IR, ¹H NMR and HRMS. The reported method is the efficient approach for the synthesis of isoquinoline derivatives.

Key words: isoquinoline, N-ethylpiperidin-4-one, ethyl 4-oxopiperidine-N-carboxylate, green synthesis