有机化学 ›› 2017, Vol. 37 ›› Issue (4): 866-872.DOI: 10.6023/cjoc201701006 上一篇    下一篇

研究论文

单质碘促进的β-酮酸酯、查尔酮以及醋酸铵的三组分反应合成多取代吡啶

赵玉英a, 王二兵a, 王颖莉b   

  1. a. 太原科技大学化学与生物工程学院 太原 030021;
    b. 山西中医学院中药药理学系 太原 030024
  • 收稿日期:2017-01-05 修回日期:2017-03-05 发布日期:2017-04-01
  • 通讯作者: 赵玉英 E-mail:zhaoyuyingtyust@163.com
  • 基金资助:

    山西省科技攻关(No.20130313015-2)资助项目.

Iodine-Promoted Three-Component Reaction of β-Keto Esters, Chalcones and Ammonium Acetate for the Synthesis of Poly-substituted Pyridines

Zhao Yuyinga, Wang Erbinga, Wang Yinglib   

  1. a. Institute of Chemical and Biological Technology, Taiyuan University of Science and Technology, Taiyuan 030021;
    b. Department of Traditional Chinese Pharmacology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030024
  • Received:2017-01-05 Revised:2017-03-05 Published:2017-04-01
  • Contact: 10.6023/cjoc201701006 E-mail:zhaoyuyingtyust@163.com
  • Supported by:

    Project supported by the Science and Technology Key Project of Shanxi Province (No. 20130313015-2).

发展了一种单质碘促进的三组分反应,以β-酮酸酯、查尔酮以及醋酸铵为底物,构筑多取代吡啶. 本方法具有原料廉价易得,底物范围广,反应操作简便等特点.

关键词: 单质碘, 多组分反应, 吡啶

A three-component reaction for the synthesis of poly-substituted pyridines from β-keto esters, chalcones and ammonium acetate promoted by iodine has been reported. Advantages of the present method include ready availability of starting materials, broad scope of substrates, and convenience of operation.

Key words: molecular iodine, muti-component reaction, pyridine