有机化学 ›› 2019, Vol. 39 ›› Issue (6): 1776-1786.DOI: 10.6023/cjoc201901006 上一篇    下一篇

研究论文

铜催化β,γ-不饱和腙与二硫/硒化物的硫/硒胺基化反应:合成硫/硒化吡唑啉类化合物

任培星a, 齐林a, 方卓越a, 吴天舒a, 高雅蒙a, 沈松a, 宋金燕a, 王力竞a,b, 李玮a,b   

  1. a 河北大学化学与环境科学学院 保定 071002;
    b 药物化学与分子诊断教育部重点实验室 河北省化学生物学重点实验室 保定 071002
  • 收稿日期:2019-01-05 修回日期:2019-01-26 发布日期:2019-02-22
  • 通讯作者: 齐林, 王力竞, 李玮 E-mail:129qilin@163.com;wanglj@hbu.edu.cn;liweihebeilab.163.com
  • 基金资助:

    国家自然科学基金(No.21702043)、河北省自然科学基金重点项目(No.B2016201031)、河北省自然科学基金青年(No.B2017201041)、河北大学"科研成果转化为教学资源"(No.KYZJX18140)资助项目.

Copper-Catalyzed Sulfeno-/Seleno-amination of β,γ-Unsaturated Hydrazones with Disulfides/Diselenides toward Sulfenylated/Selenylated Pyrazolines

Ren Peixinga, Qi Lina, Fang Zhuoyuea, Wu Tianshua, Gao Yamenga, Shen Songa, Song Jinyana, Wang Lijinga,b, Li Weia,b   

  1. a College of Chemistry & Environmental Science, Hebei University, Baoding 071002;
    b Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Baoding 071002
  • Received:2019-01-05 Revised:2019-01-26 Published:2019-02-22
  • Contact: 10.6023/cjoc201901006 E-mail:129qilin@163.com;wanglj@hbu.edu.cn;liweihebeilab.163.com
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21702043), the Science Foundation for Key Program of Hebei Province (No. B2016201031), the Science Foundation for Youths of Hebei Province (No. B2017201041), and the "Revolution of Scientific Research Results into Teaching Resources" of Hebei University (No. KYZJX18140).

发展了一类β,γ-不饱和腙与二硫/硒化物在铜催化下进行的自由基历程的硫/硒胺基化反应,合成了一系列的硫/硒化吡唑啉类化合物.该反应操作简便且反应条件温和.

关键词: 铜催化, β,γ-不饱和腙, 硫/硒胺基化, 吡唑啉

A convenient copper-catalyzed sulfeno-/seleno-amination of β,γ-unsaturated hydrazones with disulfides/diselenides via radical pathway has been developed. The protocol enables efficient access to various sulfenylated/selenylated pyrazolines under mild reaction conditions.

Key words: copper-catalyzed, β,γ-unsaturated hydrazones, sulfeno-/selenoamination, pyrazoline