过渡金属催化的芳环磺酰胺化反应研究进展

doi:10.6023/cjoc201910002

摘要/Abstract

N-芳基磺酰胺骨架广泛存在于具有生物活性的分子中，在医药领域有十分重要的应用.因此研究N-芳基磺酰胺类化合物的合成方法受到了人们的广泛关注.近年来过渡金属催化的卤代芳烃、芳基硼酸和C_Ar—H键的磺酰胺化反应得到了快速发展，为N-芳基磺酰胺类化合物的合成提供了高效、绿色的方法.按照芳基源、过渡金属催化剂、配体和磺酰胺化试剂进行分类，综述了过渡金属催化的芳环磺酰胺化反应的最新研究进展，并对此类反应的研究方向进行了展望.

关键词: N-芳基磺酰胺, 磺酰胺化, 过渡金属催化, C—N键构建, C—H键活化

The N-arylsulfonamide group is an important moiety in medicinal chemistry because of its presence in many useful molecules with potential bioactivities. As a result, the development of synthetic routes to N-arylsulfonamides has been actively investigated. In recent years, the transition metal-catalyzed sulfonamidations of aryl halides, arylboronic acids and C_Ar-H bonds have extensively investigated, providing more efficient and environmentally friendly procedures for the synthesis of N-arylsulfonamides. The recent progress in the transition metal-catalyzed sulfonamidation reactions is reviewed. The aromatic substrates, transition metal-catalysts, ligands, sulfonamidating reagents, mechanisms of the sulfonamidation reactions are mainly discussed. Finally, the future development of them is also prospected.

Key words: N-arylsulfonamides, sulfonamidation, transition metal-catalyzed, C-N bond construction, C-H bond activation

引用此文

欧阳班来, 郑燕霞, 夏克坚, 徐小玲, 王艺. 过渡金属催化的芳环磺酰胺化反应研究进展[J]. 有机化学, 2020, 40(5): 1188-1205.

Ouyang Banlai, Zheng Yanxia, Xia Kejian, Xu Xiaoling, Wang Yi. Recent Progress in Transition Metal Catalyzed Sulfonamidation of Aromatic Compounds[J]. Chinese Journal of Organic Chemistry, 2020, 40(5): 1188-1205.

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