有机化学 ›› 2023, Vol. 43 ›› Issue (3): 1012-1022.DOI: 10.6023/cjoc202211048 上一篇    下一篇

所属专题: 中国女科学家专辑

综述与进展

光催化烯烃α-酰化反应

侯虹宇a,b, 程元元a,b, 陈彬a,b, 佟振合a,b, 吴骊珠a,b,*()   

  1. a 中国科学院理化技术研究所 光化学转换与功能材料重点实验室 北京 100190
    b 中国科学院大学未来技术学院 北京 100049
  • 收稿日期:2022-11-30 修回日期:2023-01-13 发布日期:2023-01-18
  • 通讯作者: 吴骊珠
  • 基金资助:
    国家重点研发计划(2021YFA1500100); 国家重点研发计划(2022YFA1503200); 国家重点研发计划(2021YFA1500800); 国家自然科学基金(22193013); 国家自然科学基金(22088102); 国家自然科学基金(21933007); 中国科学院战略性先导科技专项(XDB17000000); 中国科学院前沿科学重点研究计划(QYZDY-SSWJSC029)

α-Acylation of Olefins via Photocatalysis

Hongyu Houa,b, Yuanyuan Chenga,b, Bin Chena,b, Chenho Tunga,b, Lizhu Wua,b()   

  1. a Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190
    b School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049
  • Received:2022-11-30 Revised:2023-01-13 Published:2023-01-18
  • Contact: Lizhu Wu
  • Supported by:
    National Key Research and Development Program of China(2021YFA1500100); National Key Research and Development Program of China(2022YFA1503200); National Key Research and Development Program of China(2021YFA1500800); National Natural Science Foundation of China(22193013); National Natural Science Foundation of China(22088102); National Natural Science Foundation of China(21933007); Strategic Priority Research Program of the Chinese Academy of Science(XDB17000000); Key Research Program of Frontier Sciences of the Chinese Academy of Science(QYZDY-SSWJSC029)

烯烃酰化反应被广泛用于制备结构丰富且高附加值的酮、醛、羧酸及其衍生物. 多组分串联N-杂环卡宾催化和过渡金属催化的烯烃α-酰化反应具有高效、高选择性的优点, 然而受限的反应模式和底物范围限制了反应的发展. 光催化烯烃α-酰化反应突破了这一限制, 具有更丰富、更广泛的底物适用范围. 以研究策略为线索, 对这一快速的研究进展进行了总结和展望.

关键词: 烯烃α-酰化, 双官能团化, 光催化, 自由基级联

The cheap and readily available olefin substrates have received much attention for the synthesis of structurally rich and high value-added ketones, aldehydes, carboxylic acids and their derivatives via α-acylation. Multicomponent tandem α-acylation of olefins achieves high efficiency and selectivity by N-heterocyclic carbene or transition metal catalysis, albeit with narrow reaction modes and substrates. Rapid growth of photocatalysis in organic transformation has introduced new methodologies to undergo the α-acylation of olefins with broad substrate scope. The research progress and prospect for the future development in this active research field is highlighted.

Key words: α-acylation of olefins, difunctionalization, photocatalysis, radical cascade