光氧化还原催化炔烃的双碳官能团化反应进展

doi:10.6023/cjoc202512019

摘要/Abstract

光氧化还原催化炔烃的双碳官能团化是有机合成领域的前沿研究方向之一. 该策略通过单电子转移、能量转移或质子耦合电子转移等机制活化底物, 实现炔烃的高效、高选择性双碳官能团化. 与传统方法相比, 可见光催化策略具有条件温和、底物适用范围广, 官能团兼容性和反应选择性好等优势, 为多取代烯烃、环状骨架及生物活性分子的高效合成提供了新范式. 本文系统综述了可见光催化炔烃双碳官能团化的最新研究进展, 重点阐述底物适用范围、反应机理、选择性调控策略以及合成应用, 并对未来发展趋势进行展望.

关键词: 光氧化还原催化, 过渡金属催化, 炔烃, 区域选择性, 双碳官能团化

Photoredox-catalyzed dicarbofunctionalization of alkynes has emerged as a cutting-edge research direction in organic synthesis. This strategy ingeniously integrates the mild activation capabilities of photochemistry with the efficient bond-forming characteristics of transition metal catalysis. Through mechanisms such as single-electron transfer, energy transfer, or proton-coupled electron transfer, highly selective dicarbofunctionalization of alkynes can be achieved under visible light conditions. Compared with traditional methods, this approach not only offers mild reaction conditions and excellent functional group tolerance, but also enables precise control over chemo-, regio-, and stereoselectivity, thereby providing a new paradigm for the efficient synthesis of polysubstituted alkenes, cyclic compounds, and bioactive molecules. This review systematically summarizes the latest advances in this field, with a focus on the substrate scope, reaction mechanisms, strategies for selectivity control, and synthetic applications, while also offering perspectives on future development trends.

Key words: Photoredox Catalysis, Transition Metal Catalysis, Alkynes, Regioselectivity, Dicarbofunctionalization

引用此文

叶富, 袁伟明. 光氧化还原催化炔烃的双碳官能团化反应进展[J]. 有机化学, doi: 10.6023/cjoc202512019.

Ye Fu, Yuan Weiming. Recent Advances in Dicarbofunctionalization of Alkynes via Photoredox Catalysis[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202512019.

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