完全未保护糖的自由基糖基化反应

doi:10.6023/cjoc202512042

综述与进展

完全未保护糖的自由基糖基化反应

王钰涓, 朱峰^*, Yang Bo^*

上海交通大学化学化工学院上海市手性药物分子工程重点实验室张江高等研究院变革性分子前沿科学中心上海 200240

收稿日期:2025-12-28 修回日期:2026-01-26
基金资助:
科技部重点研发计划(No. 2023YFA1508800),国家自然科学基金(No. 22301178, 22301180, 22577072)和抗病毒全国重点实验室开放基金(No. SKLAD-2024-0103)资助项目.

Radical glycosylation of fully unprotected sugars

Wang Yujuan^a, Zhu Feng^a,*, Yang Bo^a,*

Frontiers Science Center for Transformative Molecules (FSCTM), Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China

Received:2025-12-28 Revised:2026-01-26
Contact: *E-mail:fzchem@sjtu.edu.cn; yangbo71@sjtu.edu.cn
Supported by:
National Key R&D Program of China (Grant No. 2023YFA1508800), National Natural Science Foundation of China (Grant No. 22301178 and 22301180) and the Open Fund from the State Key Laboratory of Antiviral Drugs (No. SKLAD-2024-0103).

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摘要/Abstract

This review highlights recent advances at the forefront of carbohydrate chemistry, with a focus on protecting-group-free glycosylation. Carbohydrates are essential biological information carriers, and their synthesis relies critically on efficient glycosylation methods. Traditional approaches often involve laborious protection and deprotection steps, motivating the development of strategies that directly employ natural sugars as feedstocks. Leveraging innovative activation modes such as photocatalysis and radical-mediated pathways, these strategies enable precise, one-step transformations of native sugars into complex glycoconjugates. This approach not only streamlines synthesis and enhances atom economy but also provides a versatile platform for glycobiology research and glyco-drug development. Here, we systematically review the application of various unprotected donors in constructing C-, S-, and O-glycosidic bonds and discuss perspectives for future research directions.

Key words: unprotected glycosyl donors, radical glycosylation, stereoselectivity

引用此文

王钰涓, 朱峰, Yang Bo. 完全未保护糖的自由基糖基化反应[J]. 有机化学, doi: 10.6023/cjoc202512042.

Wang Yujuan, Zhu Feng, Yang Bo. Radical glycosylation of fully unprotected sugars[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202512042.

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