磁驱动炔烃的氢三氟甲基化反应

doi:10.6023/cjoc202604054

研究论文

磁驱动炔烃的氢三氟甲基化反应

刘浩东, 张兆鹏, 陈奕龙, 赵增典, 李新进^*

山东理工大学化学化工学院淄博 255000

收稿日期:2026-04-30 修回日期:2026-07-10
基金资助:
国家自然科学基金(No. 22101157)、先进氟氮材料全国重点实验室开放基金(No. 2026PT0002)资助项目.

Magnetic field-driven hydrotrifluoromethylation of alkynes

Liu Haodong, Zhang Zhaopeng, Chen Yilong, Zhao Zengdian, Li Xinjin^*

School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255000

Received:2026-04-30 Revised:2026-07-10
Contact: ^*E-mail: lixj@sdut.edu.cn
Supported by:
National Natural Science Foundation of China (No. 22101157) and the State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials (No. 2026PT0002).

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摘要/Abstract

发展了一种三氟甲基烯烃的绿色合成方法。本方法利用旋转磁场与金属导体, 通过电磁感应使金属棒极化, 实现三氟甲基噻嗯硫盐的单电子还原. 通过调控磁场强度和旋转频率等因素, 以水为氢源, 实现了温和条件下炔烃的氢三氟甲基化反应. 本方法无需使用催化剂及额外添加剂, 且具有很广的底物适应性和官能团兼容性, 为高效构建三氟甲基烯烃化合物提供了新策略。

关键词: 三氟甲基, 氢三氟甲基化, 炔烃, 自由基加成, 磁氧化还原

A green protocol for the synthesis of trifluoromethylated alkenes has been developed. This method utilizes a rotating magnetic field and metal rods, where electromagnetic induction polarizes the metal rods to enable single-electron reduction of trifluoromethyl thianthrenium salts. Through regulation of magnetic intensity and rotating frequency, the hydrotrifluoromethylation of alkynes is achieved by using H₂O as the hydrogen source under mild conditions. This approach requires no catalysts or additional additives, exhibits broad substrate scope and high functional group tolerance, and provides a new strategy for the efficient construction of trifluoromethylated alkenes.

Key words: Trifluoromethyl, Hydrotrifluoromethylation, Alkynes, Radical addition, Magnetoredox

引用此文

刘浩东, 张兆鹏, 陈奕龙, 赵增典, 李新进. 磁驱动炔烃的氢三氟甲基化反应[J]. 有机化学, doi: 10.6023/cjoc202604054.

Liu Haodong, Zhang Zhaopeng, Chen Yilong, Zhao Zengdian, Li Xinjin. Magnetic field-driven hydrotrifluoromethylation of alkynes[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202604054.

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