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有机化学
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有机化学 ›› 1986, Vol. 6 ›› Issue (4): 309-312. 上一篇    下一篇

研究论文

大环酮的微生物还原

李镜莲;李友荷;王大琛   

  1. 中国科学院上海有机化学研究所
  • 发布日期:1986-08-25

Microbial reduction of macrocyclic ketones

LI JINGLIAN;LI YOUHE;WANG DACHEN   

  • Published:1986-08-25

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本文报道了细菌,放线菌和丝状真菌等11株对甾族化合物有脱氢或羟化能力的微生物,对环十四酮及其同系物的生物转化结果.层析纯产物经熔点,元素分析,气-液色谱,红外,核磁,质谱等鉴定,证明有半数菌都将大环酮还原为相应的大环醇,而未发现有α,β-脱氢产物.

关键词: 气相色谱, 节杆菌属, 大环化合物, 微生物转化, 酮

Microorganisms reduced cyclododecanone, cyclotridecanone, cyclotetradecanone, cyclopentadecanone, and cyclohexadecanone to the corresponding macrocyclic alcs. (e.g., cyclododecanol). No a,b-unsatd. compound was found. Microorganisms studied included Arthrobacter simplex, Mycobacterium smegmatis, Nocardia, Fusarium graminearum, F. solani, F. lateritium, Curvularia lunata, Beauveria, Streptomyces glaucescens, and Pseudomonas putida.

Key words: GAS CHROMATOGRAPHY, ARTHROBACTER, MACROCYCLIC COMPOUNDS, MICROBIAL TRANSFORMATION, KETONE

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