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有机化学
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有机化学 ›› 1989, Vol. 9 ›› Issue (1): 89-92. 上一篇    下一篇

研究论文

2-(2'-吡啶基)-6-甲苯并噻唑及其二氯有机锡(IV)络合物的结构与抗肿瘤活性

胡盛志;施大双;黄泰山;万嘉铸;黄泽兴;杨金龙;许承辉   

  1. 厦门大学化学系;华侨大学化学系;中国科学院上海药物研究所
  • 发布日期:1989-02-25

HU SHENGZHI;SHI DASHUANG;HUANG TAISHAN;WAN JIAZHU;HUANG ZEXING;YANG JINLONG;XU CHENGHUI   

  • Published:1989-02-25

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二氯有机锡(IV)含双氮配体络合物具有抗肿瘤活性. 本文报道了2-(2'-吡啶基)-6-甲苯并噻唑及其二氯二乙基合锡(IV)反应产物的谱学表征、晶体结构和抗癌活性筛选的主要结果.

关键词: 晶体结构测定, 吡啶 P, 抗癌药, 甲苯, Ｘ射线衍射分析, 有机金属化合物, 构型, 苯并噻唑 P, 锡络合物

The crystal structures of the title compounds were determine by x-ray diffractometry. The ligand 2-(2'-pyridyl)-6-methylbenzothiazole (L) is monoclinic, space group P21/n, with a 5.749(1), b 15.383(1), c 12.449(2) ? and b 95.68(1)? Z = 4; R = 0.034. The complex SnEt2Cl2L is monoclinic, space group P21/c, with a 14.755(2), b 9.447(5), c 13.835(6) ? and b 95.29(2)? Z = 4; R = 0.067. The S atom in the structure forms a 5-member ring, which is consistent with IR and NMR results.

Key words: CRYSTAL STRUCTURE DETERMINATION, PYRIDINE P, ANTICARCINOGEN, METHYLBENZENE, X-RAY DIFFRACTION ANALYSIS, ORGANOMETALLIC COMPOUNDS, CONFIGURATION, BENZOTHIAZOLE P, TIN COMPLEX

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