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有机化学
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有机化学 ›› 1992, Vol. 12 ›› Issue (1): 54-57. 上一篇    下一篇

研究论文

新马兜铃内酯的晶体结构

陈元柱;吴锵金;徐本杰;楼凤昌;丁林生   

  1. 中国科学院福建物质结构研究所;中国药科大学天然药化教研室
  • 发布日期:1992-02-25

The crystal structure of Neo-aristolactone

CHEN YUANZHU;WU QIANGJIN;XU BENJIE;LOU FENGCHANG;DING LINSHENG   

  • Published:1992-02-25

被引次数

6

从绵毛马兜铃的根茎中分离出一种新的倍半萜内酯, 它的分子式由高分辨质谱数据确定为C~1~5H~2~0O~2, 它的结构用单晶X射线衍射法测定, 晶体属三斜晶系, 空间群为P1, a=0.6275(3)nm, b=0.8057(4)nm, c=1.3622(6)nm; α=88.78(4)°,β=91.44(4)°, γ=105.20(4)°; Z=2.3107。

关键词: 内酯, 马兜铃内酯, 晶体结构测定, 马兜铃属, 抗肿瘤药, 倍半萜

A new sesquiterpenoid lactone (I), neoaristolactone, was isolated from the root of Aristolochia mollissima Hance. This crystal belongs to the triclinic system, space group is P1, with a = 0.6275(3) nm, b = 0.8075(4) nm, c = 1.3622(6) nm; a = 88.78(4)? b = 91.44(4)? g = 105.20(4)? Z = 2.3107, reflections were collected on a Rigaku AFC5R diffractometer with monochromatized MoKa radiation and corrected for Lp factors and empirical absorption, of which 1468 observed reflections were used in structural determination The structure was refined to a final R value of 0.079 by the full-matrix least-squares.

Key words: CRYSTAL STRUCTURE DETERMINATION, LACTONES, ARISTOLOCHIA, ANTITUMOR DRUGS, SESQUITERPENE

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