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有机化学
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有机化学 ›› 1992, Vol. 12 ›› Issue (6): 577-582. 上一篇    下一篇

研究论文

芳酰基硒脲合成及其对O~2清除作用的EPR研究

徐思柯;周澄明;何敏;郭惠菊;孙勇   

  1. 中国科学院上海有机化学研究所;上海师范大学化学系
  • 发布日期:1992-12-25

The synthesis and EFR study of aroylselenoureas as an O~ 2 scavenger

XU SIKE;ZHOU CHENGMING;HE MIN;GUO HUIJU;SUN YONG   

  • Published:1992-12-25

芳酰基硒脲的合成试剂芳酰基异硒氰酸脂是极不稳定的化合物。通过硒氰化铅在非极性溶剂苯中同芳酰氯反应能简便、稳定和可靠地合成芳酰基异硒氰酸脂、从而与芳胺反应能合成一系列芳酰基硒脲。经EFR 研究其对超氧阴离子自由基O~2具有明显的清除作用。

关键词: 顺磁共振, 芳酰基, 亲核反应, 加成反应, 硒脲, 芳香族胺, 异硒氰酸脂

A series of new aroylselenoureas was synthesized by reaction of lead selenocyanate with aroyl chlorides in nonpolar solvents to afford very active aroyl isoselenocyanates, followed by the direct addition with some arylamines in one pot. The EPR study indicates that the activity of aroylselenoureas e.g., PhCONHC(Se)NHPh as a mol. oxygen anion radical cavenger is very significant.

Key words: NUCLEOPHILIC REACTION, PARAMAGNETIC RESONANCE, AROYL, ADDITION REACTION, SELENOUREA, AROMATIC AMINES

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